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KMID : 0191120030180020299
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Journal of Korean Medical Science
2003 Volume.18 No. 2 p.299 ~ p.300
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Flumazenil-induced Ballism
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Kwang Soo Lee/Joong Seok Kim
Seok Bum Ko/Yeong Bin Choi/Kwang Soo Lee
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Abstract
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Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.
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KEYWORD
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Ballism, Flumazenil, GABA, Dopamine,
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